Majestic Tree H
UKC Forum Member
Registered: Nov 2005
Location: New Market Va
Posts: 4670 |
Ivermectin "Overdose" levels in Canines As a Rule Per MerckVet.
is 10x the Max. dosage used for Mange which is around .28 mg per Pound or .6 mg per Kg.
So 10 X .28 mg = 2.8 mg per pound would Be Max and Overdose Level ..
"At least 10 times the normal dose of ivermectin is needed for toxic reactions."
But Remember only .1 mg per Pound is all that is required for Ivermectin to Control Some GI Parisites "Worms"
Ivermectin is an avermectin and a fermentation product of Streptomyces avermitilis (also see Anthelmintics: Macrocyclic Lactones). It acts as a GABA agonist, causing paralysis in susceptible arthropods and nematodes. It is used in small animals for treatment of Sarcoptes scabeii, Otodectes cynotis, Cheyletiella blakei, C yasguri, and Demodex canis; in cattle for psoroptic mange, lice, and Hypoderma larvae; in horses for equine filarial dermatitis from Onchocerca cervicalis; and in swine for Sarcoptes scabeii.
In small animals, all use for skin conditions is extra-label in the USA. For Demodex, the dosage is 0.3–0.6 mg/kg, PO, sid until 2 negative skin scrapings 1 mo apart. For Sarcoptes, Otodectes, and Cheyletiella, the dosage is 0.3 mg/kg, PO, repeated in 2 wk. In cattle, 0.2 mg/kg is given as a single SC injection for Psoroptes and lice. In horses, 0.2 mg/kg, PO, kills microfilariae but not adult Onchocerca cervicalis, so relapse may be noted within 2 mo of treatment. In swine, the dosage is 0.3 mg/kg, SC, repeated in 2 wk, or 0.1–0.2 mg/kg in feed for 7 days.
In mammals, GABA is found only in the CNS and does not readily cross the blood-brain barrier. At least 10 times the normal dose of ivermectin is needed for toxic reactions. Ataxia, depression, and visual impairment develop in horses given 2 mg/kg, PO. In cattle, 4 mg/kg by drench or 8 mg/kg, SC, leads to listlessness and ataxia; 30 mg/kg induces ataxia in swine.
Some dog breeds (Collies, Shetland Sheepdogs, Old English Sheepdogs, Australian Collies, and their crosses) have an abnormality in the blood-brain barrier associated with a mutation of multiple drug resistance gene MDR1, permitting increased ivermectin into the CNS and therefore toxicity. Dogs that are homozygous for the mutation produce a severely truncated P-glycoprotein (<10% of the normal amino acid sequence) and will develop ivermectin toxicity at any of the dosages used to treat demodicosis. The critical point seems to be 120–150 ìg/kg, at which transient, nonfatal clinical signs (mydriasis, ataxia, tremors) are seen. At higher doses, collapse, coma, and respiratory collapse may develop. Similar idiosyncratic reactions may develop in any breed, so a gradually increasing dose (daily progression of 50, 100, 150, 200, then 300 ìg/kg) should be given to identify susceptible individuals. Administration should be stopped if any side effects are seen. One cat treated with 4 mg of the oral paste (~70 ìg/kg) showed ataxia, blindness, tremors, and mydriasis, with retinal atrophy in one eye 10 hr later.
Equimax Horse Wormer .. 1-tube = 6.42 Grams Treats 1,320 of Horse Weight or .0049 Grams per pound or 4.90 mg per Pound Markings.
Each 1 pound Horse Treatment Contains .091 mg of Ivermectin and .682 mg of Praziquantel .
The Min. Required Dosage for Canine Tapeworms is 2.27 mg Per pound of Praziquantel .
The Entire Tube has 900.70 mg so 900.7 divided by 2.27 = 397 pounds of Canine Treatment for Tapeworms.
Ingredients :
1) Ivermectin - 1.87% per Volume .. Formula 6.42 X 1.87% = .12005 Grams of Ivermectin or 120.05 Mg
2) Praziquantel - 14.03% per Volume .. Formula 6.42 X 14.03% = .9007 Grams of Praziquantel or 900.70 Mg
3) Some kind of " Paste with Flavor " .. Formula 100% - 1.87% - 14.03% = 84.10% or 6.42 X 84.10% = 5.40 Grams of "Paste and Flavor" or 5400 mg of Nothing ..
Now I have no Idea how much People are Giving their Dogs !!! I have heard Quantizes of a "Pea" size to about " 1" long Squirt "
Lets just say if you divided it by 1 gram sizes which I guessing would be around a Pea Size ..
You Would be Giving your dog 18.17 mg of Ivermectin !!!
Now the Dosage of Ivermectin Required to Work on Internal GI parasites " Worms" is .1 mg per pound of Dog weight ..
So a 50 pound dog would ONLY require .5 mg of Ivermectin TOTAL But with that "Pea" Size Dosage you gave your dog 18.17 mg - 36.7 Times more than required ...
Ok Praziquantel, That same Dog 50 pounds Requires a Minimum dosage of 2.5 mg per pound to Do ANYTHING against Tapeworms . So 50 pounds X 2.5 mg = 125 mg of Praziquantel .
The "Pea" Size Dosage DID Delivered 140 mg of Praziquantel which would cover the Tapeworm Treatment Required .
Cost For Worm Treatment for a 50 pound dog .. $ 12.00 per Tube divided by 6.42 = $ 1.87
Zimecterin Gold Horse Wormer .. 1-tube = 7.35 Grams Treats 1,250 of Horse Weight or .0058 Grams per pound or 5.88 mg per Pound Markings.
Each 1 pound Horse Treatment Contains .0912 of Ivermectin and .456 mg of Praziquantel .
The Min. Required Dosage for Canine Tapeworms is 2.27 mg Per pound of Praziquantel .
The Entire Tube only has 570 mg so 570 divided by 2.27 = 252 pounds of Canine Treatment for Tapeworms
Ingredients :
1) Ivermectin - 1.55% per Volume .. Formula 7.35 X 1.55% = .1140 Grams of Ivermectin or 114.00 Mg
2) Praziquantel - 7.75% per Volume .. Formula 7.35 X 7.75% = .570 Grams of Praziquantel or 570 Mg
3) Some kind of " Paste with Flavor " .. Formula 100% - 1.55% - 7.75% = 90.70% or 7.35 X 90.70% = 6.67 Grams of "Paste and Flavor" or 6670 mg of Nothing ..
Now I have no Idea how much People are Giving their Dogs !!! I have heard Quantizes of a "Pea" size to about " 1" long Squirt "
Lets just say if you divided it by 1 gram sizes which I guessing would be around a Pea Size ..
You Would be Giving your dog 15.51 mg of Ivermectin !!!
Now the Dosage of Ivermectin Required to Work on Internal GI parasites " Worms" is .1 mg per pound of Dog weight ..
So a 50 pound dog would ONLY require .5 mg of Ivermectin TOTAL But with that "Pea" Size Dosage you gave your dog 15.51 mg - 32.2 Times more than required ...
Ok Praziquantel, That same Dog 50 pounds Requires a Minimum dosage of 2.5 mg per pound to Do ANYTHING against Tapeworms . So 50 pounds X 2.5 mg = 125 mg of Praziquantel .
The "Pea" Size Dosage Only Delivered 77.55 mg of Praziquantel which would DO NOTHING for the Tapeworm Treatment Required .
Cost For Worm Treatment for a 50 pound dog .. $ 12.00 per Tube divided by 7.35 = $ 1.63
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Steve Morrow "Saltlick Majestic's"
"Never Have Hounds Or Kids And You Won't Get Your Heart Broke"!!
540-421-2875
PR, Saltlick's Blue Misty Linga "Bluetick Coonhound"
French X American Hounds
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