UKC Forums - Fleas

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Posted by tn backwoods on 07-06-2012 02:32 PM:

Fleas

What is the best out there to kill fleas and keep them away?

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Posted by Chris McCrary on 07-06-2012 03:47 PM:

Comfortes (sp?) flea pill

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Posted by BWSupplies on 07-06-2012 04:24 PM:

I picked a pack of Comfortis pills the other day and seen the Trifexis pills.. They are made by the same company as Comfortis but it also gets heart worms, whip worms, hook worms and round worms.. It wasn't bot $3.00 more

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Posted by Cynthia on 07-06-2012 05:27 PM:

read the reviews on trifexis. some were really bad.

how much was your comfortis?

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Posted by imacorgimom on 07-06-2012 05:27 PM:

Be aware that neither Trifexis nor Comfortis has been tested on nor approved for use in breeding animals.

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Posted by Cynthia on 07-06-2012 06:18 PM:

according to the product label, comfortis was tested. its states to use caution. also note that the test group was given way over the recommended dosages.

Animal Safety:
COMFORTIS chewable tablets were tested in pure and mixed breeds of healthy dogs in well-controlled clinical
and laboratory studies. No dogs were withdrawn from the field studies due to treatment-related adverse reactions.
In a dose tolerance study, COMFORTIS chewable tablets were administered orally to adult Beagle dogs at
average doses of up to 100 mg/kg once daily for 10 consecutive days (16.7 times the maximum recommended monthly dose). Vomiting was seen in 5 of 6 treated dogs during the first 6 days of treatment, usually within 2.5
hours of dosing. Treated females lost weight early in the treatment period, but their weights were similar to control
dogs by the end of the 24-day study. COMFORTIS chewable tablets were not associated with any clinically
significant changes in hematology, blood coagulation or urinalysis parameters; however, mild elevations in ALT
occurred in all dogs treated with COMFORTIS chewable tablets. By day 24, ALT values had returned to near
baseline levels. Phospholipidosis (vacuolation) of the lymphoid tissue was seen in all dogs treated with
COMFORTIS chewable tablets, the long-term effects of which are unknown.
In a margin of safety study, COMFORTIS chewable tablets were administered orally to 6-week-old Beagle
puppies at average doses of 1.5, 4.4, and 7.4 times the maximum recommended dose at 28-day intervals over a
6-month period. Vomiting was observed across all groups, including the control. Increased vomiting was observed
at elevated doses, usually within 1 hour following administration. Vomiting at all doses decreased over time and
stabilized when puppies were 14 weeks of age. The average daily and total weight gains of treated dogs were
smaller than control dogs and were dose dependent. COMFORTIS chewable tablets were not associated with
clinically significant changes in hematology, clinical chemistry, coagulation or urinalysis parameters.
Phospholipidosis (vacuolation) of the lymphoid tissue was seen in some dogs in the 4.4X group and all dogs in the
7.4X group. The long term effects of phospholipidosis are unknown. Treatment with COMFORTIS chewable
tablets was not associated with any other clinically significant adverse clinical observations, gross necropsy or
histopathological changes.
In a reproductive safety study, COMFORTIS chewable tablets were administered orally to female Beagles at 1.3
and 4.4 times the maximum recommended therapeutic dose every 28 days prior to mating, during gestation, and
during a six-week lactation period. No treatment-related adverse effects were noted for conception rates in the
dams, or for mortality, body temperature, necropsy, or histopathology findings for the dams or puppies. One dam
from each treatment group experienced early pregnancy loss and one additional high dose dam aborted late term.
The treated dams experienced more vomiting, especially at one hour post-dose, than the control dams. Puppies
from dams treated at 1.3 times the maximum recommended therapeutic dose had lower body weights than
puppies from control dams. Although puppy mortality between treated and control dams was not different, the
puppies from the treated dams experienced more lethargy (4.4X group only), dehydration, weakness and felt cold
to the touch (4.4X group only) than puppies from control dams.
A pilot study without a control group was conducted to analyze milk from three lactating dogs treated with an
experimental formulation of spinosad at 1.5 times the maximum recommended dose administered at day 28 of
gestation and 24 hours prior to parturition. The data demonstrated that spinosyns were excreted in the milk of
these dogs. Mortality and morbidity were greatest in puppies from the dam with the highest spinosyns level in milk.
The spinosad milk: reference plasma exposure ratio calculated from this study ranged from 2.2 to 3.5.
In well-controlled field studies, COMFORTIS chewable tablets were administered safely in conjunction with other
frequently used veterinary products, such as vaccines, anthelmintics, antibiotics, steroids, flea and tick control
products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, and prescription diets.
Changes in hematology, clinical chemistry and urinalysis values were compared pre-and post-study and were
unremarkable.

Posted by BWSupplies on 07-06-2012 06:21 PM:

quote:
Originally posted by Cynthia
read the reviews on trifexis. some were really bad.

how much was your comfortis?

a 6 pack was $86 for the 40 to 60lbs from the local vet..

Posted by hayrakeswildjoe on 07-06-2012 08:55 PM:

just gave my dogs trifectus yesterday,and almost all fleas are gone,wormed up and heartworm preventative,gave them a half pill each of the 60-100 lb size,they seem o.k so far.

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